Searchable abstracts of presentations at key conferences on calcified tissues

ba0004lb1 | (1) | ICCBH2015

Maternal vitamin D depletion disrupts neonatal skeletal development in mice

Buckley Harriet , Borg Stephanie , Nicholson Kirsty , Kinch Mark , Hughes David , Skerry Tim , Bishop Nick

Fractures in infancy raise the spectre of child abuse; it has been suggested that lack of vitamin D could result in bone abnormalities that could predispose to fractures. We utilised a mouse model system to investigate whether vitamin D deficiency in utero alters early bone growth and development.C57BL/6 female mice received vitamin D deficient or replete diet for 6 weeks, then mated and continued on their respective diets until weaning. Pups were culled...